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产品概述
| 名称 | SW620 (人结肠癌细胞) (STR鉴定正确) |
| 别称 | SW-620; SW 620; SW.620 |
| 种属 | 人类 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，100%, 温度：37℃
|
| 培养方案B（可选） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 1.该细胞推荐使用Leibovitz's L-15培养基进行培养，Leibovitz's L-15不可以通入二氧化碳，会产生细胞毒性；2.如您没有无二氧化碳的培养箱，可使用DMEM替代Leibovitz's L-15，使用DMEM培养基时即可正常通入5%二氧化碳；3.配套专用培养基默认Leibovitz's L-15配置，如需DMEM配方，请联系销售下单备注更改。 |
| 背景描述 | SW620细胞是从一个51岁男性白人组织中分离得到的，由A·Leibovitz等从一个淋巴结建株。SW620细胞主要由无绒毛的小园球细胞和双极细胞组成;SW620细胞仅合成少量癌胚抗原(CEA)，在裸鼠中有高度的致瘤性。 |
| 年龄（性别） | 男性；51岁 |
| 组织来源 | 结直肠腺癌，来自转移淋巴结 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肠癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~20-26 hours |
| 致瘤性 | Yes, in nude mice (Tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 1×10^7 cells). |
| 抗原表达情况 | Blood Type A; Rh+ |
| 基因表达情况 | Carcinoembryonic antigen (CEA) 0.15 ng/10^6 cells/10 days; transforming growth factor alpha; matrilysin. The cells are negative for expression of CSAp (CSAp-) and colon antigen 3, negative. The cells are positive for keratin by immunoperoxidase staining. The line is positive for expression of c-myc, K-ras, H-ras, N-ras, Myb, sis and fos oncogenes. |
| 保藏机构 | ATCC; CCL-227 ECACC; 87051203 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 13,14 D2S1338 17,24 D3S1358 16 D5S818 13 D7S820 8,9 D8S1179 13 D13S317 12 D16S539 9,13 D18S51 13 D19S433 13 D21S11 30,30.2 FGA 24 PentaD 9,15 PentaE 10 TH01 8 TPOX 11 vWA 16 D6S1043 11,12 D12S391 17 D2S441 10,15 -
STR鉴定图
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参考文献
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Biotin-decorated celastrol-loaded ZIF-8 nanoparticles induce ferroptosis for colorectal cancer therapy(2024/02/29)
作者：Jie Chen, Yan Liu, Yanting You
期刊：MATERIALS & DESIGN
DOI：10.1016/j.matdes.2024.112814
影响因子 ：8.400
引用产品：CL-0225
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Structural elucidation of an acidic polysaccharide from Citrus grandis ‘Tomentosa’ and its anti-proliferative effects on LOVO and SW620 cells(2019/10/01)
作者：Ruiyi Fan, Yuming Xie, Congyi Zhu
期刊：International Journal of Biological Macromolecules
DOI：10.1016/j.ijbiomac.2019.07.117
影响因子 ：8.200
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A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer(2019/11/04)
作者：Daoxiong Ye, Sisi Wang, Ying Huang
期刊：Cancer Cell International
影响因子 ：5.800
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Circ_0011385 knockdown inhibits cell proliferation, migration and invasion, whereas promotes cell apoptosis by regulating miR-330-3p/MYO6 axis in colorectal cancer(2022/01/26)
作者：Jing Wang, Shaobo Ke, Yi Gong
期刊：Biomedical Journal
影响因子 ：5.500
引用产品：164210 164210-50 CL-0096 CL-0144 CL-0223 CL-0225 PM150110 PM150210
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Raltitrexed as a synergistic hyperthermia chemotherapy drug screened in patient-derived colorectal cancer organoids(2021/8/15)
作者：Lisi Zeng, Quanxing Liao, Haoran Zhao
期刊：Cancer Biology & Medicine
DOI：10.20892/j.issn.2095-3941.2020.0566
影响因子 ：5.500
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Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma(2021/8/17)
作者：Hua Gong, Qiang Niu, Yi Zhou
期刊：Bioengineered
DOI：10.1080/21655979.2021.1961657
影响因子 ：4.900
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Circ_0056618 enhances PRRG4 expression by competitively binding to miR-411-5p to promote the malignant progression of colorectal cancer(2022/08/02)
作者：Bo Zhang, Wenbin Cao, Yang Liu
期刊：MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI：10.1007/s11010-022-04525-x
影响因子 ：4.300
引用产品：164210 164210-50 CL-0096 CL-0144 CL-0223 CL-0225 PM150710 PM151010
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MicroRNA‑129 inhibits colorectal cancer cell proliferation, invasion and epithelial‑to‑mesenchymal transition by targeting SOX4(2021/03/24)
作者：Zhiping Chen, Tianyu Zhong, Jinghua Zhong
期刊：Oncology Reports
影响因子 ：4.200
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MicroRNA‑129 inhibits colorectal cancer cell proliferation, invasion and epithelial‑to‑mesenchymal transition by targeting SOX4(2021/03/24)
作者：Zhiping Chen, Tianyu Zhong, Jinghua Zhong
期刊：Oncol Rep
影响因子 ：4.136
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The bromodomain and extra-terminal domain inhibitor JQ1 synergistically sensitizes human colorectal cancer cells to topoisomerase I inhibitors through repression of Mre11-mediated DNA repair pathway(2020/09/26)
作者：Linping Lei, Xuqin Xie, Long He
期刊：Investigational New Drugs
DOI：10.1007/s10637-020-01014-0
影响因子 ：3.400
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CircCSNK1G1 Contributes to the Development of Colorectal Cancer by Increasing the Expression of MYO6 via Competitively Targeting miR-455-3p(2020/10/02)
作者：Xianming Huang, Xiaohua Shen, Lixiang Peng
期刊：Cancer Management and Research
影响因子 ：3.300
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NDRG4 sensitizes CRC cells to 5-FU by upregulating DDIT3 expression(2021/9/13)
作者：Ruikai Li, Chenxiang He, Liangliang Shen
期刊：Oncology Letters
影响因子 ：2.900
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microRNA-4429-5p suppresses the malignant development of colon cancer by targeting matrix metalloproteinase 16(2021/08/26)
作者：Wei Li, Zhe Song, Nan Jia
期刊：In Vitro Cellular & Developmental Biology-Animal
DOI：10.1007/s11626-021-00603-4
影响因子 ：2.723
引用产品：CL-0050 CL-0096 CL-0144 CL-0223 CL-0225 PM150710 PM150910 PM151010
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Bone Morphogenetic Protein 1 Targeting COL1A1 and COL1A2 to Regulate the Epithelial-Mesenchymal Transition Process of Colon Cancer SW620 Cells(2020/03/01)
作者：Xijia Zhu, Xishun Luo, Shiyu Jiang
期刊：Journal of Nanoscience and Nanotechnology
影响因子 ：0.000
引用产品：CL-0225
![SCC-25 [SCC 25; SCC25] (人舌鳞癌细胞)(STR鉴定正确)](/Public/upfile/pic/xbx/CL-0569-1.jpg)
