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| 名称 | U-87 MG (人脑星形胶质母细胞瘤细胞) (STR鉴定正确) |
| 别称 | U-87MG; U-87 MG; U87 MG; U-87-MG; U87-MG; U87MG; U-87; U87; 87 MG; 87MG |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 该细胞容易聚团，可使用多聚-L-赖氨酸溶液包被后改善，建议提前配备多聚-L-赖氨酸溶液（货号 PB180523）。 |
| 背景描述 | U-87 MG细胞是由Ponten·J等建立，源于恶性神经胶质瘤；U-87 MG细胞裸鼠皮下接种可成瘤。 |
| 年龄（性别） | 男性 |
| 组织来源 | 脑星形胶质母细胞瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 胶质瘤细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~36-72 hours |
| 致瘤性 | Yes, in nude mice inoculated subcutaneously with 1×10^7 cells. |
| 保藏机构 | ATCC; HTB-14 ECACC; 89081402 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,11 D2S1338 20,23 D3S1358 16,17 D5S818 11,12 D7S820 8,9 D8S1179 10,11 D13S317 8,11 D16S539 12 D18S51 13 D19S433 15,15.2 D21S11 28,32.2 FGA 18,24 PentaD 9,14 PentaE 7,14 TH01 9.3 TPOX 8 vWA 15,17 D6S1043 11,18 D12S391 18,21 D2S441 10,11 -
STR鉴定图
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参考文献
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A Dual-Functional Persistently Luminescent Nanocomposite Enables Engineering of Mesenchymal Stem Cells for Homing and Gene Therapy of Glioblastoma(2017/02/06)
作者：Shuqi Wu, Chengxiong Yang, Xiuping Yan
期刊：Advanced Functional Materials
影响因子 ：19.924
引用产品：CL-0238
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A nitric-oxide driven chemotactic nanomotor for enhanced immunotherapy of glioblastoma(2023/02/20)
作者：Huan Chen, Ting Li, Zhiyong Liu
期刊：Nature Communications
DOI：10.1038/s41467-022-35709-0
影响因子 ：16.600
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Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis(2021/12/06)
作者：Xiucai Chen, Guixue Tang, Wenhua Luo
期刊：Journal Of The American Chemical Society
影响因子 ：16.383
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Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides(2022/08/06)
作者：Zhanchi Zhu, Yuanxin Zhai, Ying Hao
期刊：Journal of Extracellular Vesicles
影响因子 ：16.000
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Controlling dielectric loss of biodegradable black phosphorus nanosheets by iron-ion-modification for imaging-guided microwave thermoacoustic therapy(2022/07/01)
作者：Xiaoyu Chen, Shanxiang Zhang, Jiaqian Liu
期刊：BIOMATERIALS
DOI：10.1016/j.biomaterials.2022.121662
影响因子 ：14.000
引用产品：CL-0238
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A biosensor for D-2-hydroxyglutarate in frozen sections and intraoperative assessment of IDH mutation status(2023/12/12)
作者：Wen Zhang, Mu Yang, Gang Wang
期刊：BIOSENSORS & BIOELECTRONICS
DOI：10.1016/j.bios.2023.115921
影响因子 ：12.600
引用产品：CL-0238
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Profiling demethylase activity using epigenetically inactivated DNAzyme(2022/03/18)
作者：Juan Huang, Jiao Wang, Zhenkun Wu
期刊：Biosensors & Bioelectronics
DOI：10.1016/j.bios.2022.114186
影响因子 ：12.600
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Chitinase-3 like-protein-1 promotes glioma progression via the NF-κB signaling pathway and tumor microenvironment reprogramming.(2022/10/03)
作者：Ting Zhao, Jianming Zeng, Yujie Xu
期刊：Theranostics
影响因子 ：12.400
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Epigenetically regulated lncRNAs dissect the intratumoural heterogeneity and facilitate immune evasion of glioblastomas(2023/03/05)
作者：Dahua Xu, Meng Cao, Bo Wang, Xiaoman Bi
期刊：Theranostics
影响因子 ：12.400
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Hypoxia induced ferritin light chain (FTL) promoted epithelia mesenchymal transition and chemoresistance of glioma(2020/07/16)
作者：Junhui Liu, Lun Gao, Na Zhan
期刊：Journal Of Experimental & Clinical Cancer Research
DOI：10.1186/s13046-020-01641-8
影响因子 ：11.300
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Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma(2021/05/11)
作者：Chenyu Ding, Xuehan Yi, Xiangrong Chen
期刊：Journal Of Experimental & Clinical Cancer Research
DOI：10.1186/s13046-021-01942-6
影响因子 ：11.300
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The miR-145–MMP1 axis is a critical regulator for imiquimod-induced cancer stemness and chemoresistance(2022/03/28)
作者：Shan Zhu, Ning Yang, Chao Niu
期刊：Pharmacological Research
DOI：10.1016/j.phrs.2022.106196
影响因子 ：9.300
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Peptidic heterodimer-based radiotracer targeting fibroblast activation protein and integrin αvβ3(2024/01/26)
作者：Kehuang Liu, Tao Jiang, Wanqian Rao
期刊：EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
DOI：10.1007/s00259-024-06623-y
影响因子 ：9.100
引用产品：CL-0238
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Noninvasive imaging of FAP expression using positron emission tomography: A comparative evaluation of a [18F]-labeled glycopeptide-containing FAPI with [18F]FAPI-42(2023/06/02)
作者：Jiawen Huang, LiLan Fu, XiaoJun Zhang
期刊：EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
DOI：10.1007/s00259-023-06282-5
影响因子 ：9.100
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SLC1A5 enhances malignant phenotypes through modulating ferroptosis status and immune microenvironment in glioma(2022/12/24)
作者：Liying Han, Jinpeng Zhou, Leiyang Li
期刊：Cell Death & Disease
DOI：10.1038/s41419-022-05526-w
影响因子 ：9.000
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Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma(2021/07/21)
作者：Guodong Zhu, Jing Yu, Zhengyu Sun
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-04000-3
影响因子 ：9.000
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MicroRNA-22 represses glioma development via activation of macrophage-mediated innate and adaptive immune responses(2022/03/12)
作者： JiajieTu, Yilong Fang, Dafei Han
期刊：Oncogene
DOI：10.1038/s41388-022-02236-7
影响因子 ：8.000
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BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation(2023/12/11)
作者：Weiwei Li, Xuxu Fan, Zhisheng Xu
期刊：JOURNAL OF CELL BIOLOGY
影响因子 ：7.800
引用产品：CL-0238
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Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5′-UTR RNA G-Quadruplexes(2024/01/25)
作者：Maolin Li, Letian Dai, Zhuoyu Gao
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.3c01773
影响因子 ：7.300
引用产品：CL-0238
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A novel prognostic related lncRNA signature associated with amino acid metabolism in glioma(2023/04/11)
作者：Qiang Lei, Bo Yuan, Kun Liu
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1014378
影响因子 ：7.300
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Novel piperazine based benzamide derivatives as potential anti-glioblastoma agents inhibiting cell proliferation and cell cycle progression(2021/10/08)
作者：Yingmei Lu, Yiyue Feng, Zhao Li
期刊：European Journal Of Medicinal Chemistry
DOI：10.1016/j.ejmech.2021.113908
影响因子 ：7.088
引用产品：CL-0238
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Neogenin suppresses tumor progression and metastasis via inhibiting Merlin/YAP signaling(2023/02/06)
作者：Xiaohan Hu, Li Li, Fang Li
期刊：Cell Death Discovery
DOI：10.1038/s41420-023-01345-w
影响因子 ：7.000
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N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation(2021/09/10)
作者：Junfang Li, Xiaoling Hu, Tian Luo
期刊：European Journal Of Medicinal Chemistry
DOI：10.1016/j.ejmech.2021.113817
影响因子 ：6.700
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Design, synthesis, and biological evaluation of novel spirocyclic compounds as potential anti-glioblastoma agents(2023/06/25)
作者：Heping Zhu, Xiaomin Song, Yihui Pan
期刊：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1016/j.ejmech.2023.115595
影响因子 ：6.700
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Therapeutic effects against high-grade glioblastoma mediated by engineered induced neural stem cells combined with GD2-specific CAR-NK(2023/07/07)
作者：Weihua Liu, Yu Zhao, Zhongfeng Liu
期刊：CELLULAR ONCOLOGY
DOI：10.1007/s13402-023-00842-5
影响因子 ：6.600
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Carbon Ion Irradiation Downregulates Notch Signaling in Glioma Cell Lines, Impacting Cell Migration and Spheroid Formation(2022/10/24)
作者：Vivek Kumar, Mohit Vashishta, Lin Kong
期刊：Cells
影响因子 ：6.000
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CAR-T-Cell Therapy for Solid Tumors Positive for Fibronectin Extra Domain B(2022/09/14)
作者：Zhijie Zhang, Chang Liu, Zhe Yang
期刊：Cells
影响因子 ：6.000
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Tanshinone I induces apoptosis and protective autophagy in human glioblastoma cells via a reactive oxygen species‑dependent pathway(2020/02/13)
作者：Shangguan Jian, Liang Chen, Lian Minxue
期刊：International Journal of Molecular Medicine
影响因子 ：5.400
引用产品：CL-0238
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Decreased RNA m6A methylation enhances the process of the epithelial mesenchymal transition and vasculogenic mimicry in glioblastoma(2022/02/15)
作者：Min Tao, Xiaoyu Li, Lei He
期刊：American Journal of Cancer Research
DOI：PMID:35261810
影响因子 ：5.300
引用产品：CL-0238
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lncRNA TUSC7 sponges miR-10a-5p and inhibits BDNF/ERK pathway to suppress glioma cell proliferation and migration(2023/04/14)
作者：Runhui Wang, Jia Wang, Yuanyu Wang
期刊：Aging-US
影响因子 ：5.200
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FDX1 serves as a prognostic biomarker and promotes glioma progression by regulating the immune response(2023/06/10)
作者：Guangying Zhang, Liangfang Shen, Zhanzhan Li
期刊：Aging-US
影响因子 ：5.200
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Isobavachalcone’s Alleviation of Pyroptosis Contributes to Enhanced Apoptosis in Glioblastoma: Possible Involvement of NLRP3(2022/09/02)
作者：Yueshan Wu, Jing Chang, Juanjuan Ge
期刊：MOLECULAR NEUROBIOLOGY
DOI：10.1007/s12035-022-03010-2
影响因子 ：5.100
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Lemur tyrosine kinase 2 has a tumor-inhibition function in human glioblastoma by regulating the RUNX3/Notch pathway(2023/06/02)
作者：Lei Zhang, Peng Luo, Xinggang Mao
期刊：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
DOI：10.1016/j.bbamcr.2023.119509
影响因子 ：5.100
引用产品：164210-50 CL-0012 CL-0237 CL-0238 CL-0458 CL-0583 PB180120 PM150210 PM150410
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GD2 CAR-T cells in combination with Nivolumab exhibit enhanced antitumor efficacy(2023/03/24)
作者：Guangji Zhang, Yu Zhao, Zhongfeng Liu
期刊：Translational Oncology
DOI：10.1016/j.tranon.2023.101663
影响因子 ：5.000
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Circular RNA 0010117 promotes aggressive glioblastoma behavior by regulating the miRNA-6779-5p/SPEN axis(2022/09/07)
作者：Xuanyong Yang, Yue Liu, Xinhui Zhou
期刊：Translational Oncology
DOI：10.1016/j.tranon.2022.101515
影响因子 ：5.000
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Integration analysis of single-cell and spatial transcriptomics reveal the cellular heterogeneity landscape in glioblastoma and establish a polygenic risk model(2023/06/15)
作者：Yaxuan Liu, Zhenyu Wu, Yueyuan Feng
期刊：Frontiers in Oncology
影响因子 ：4.700
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The Circ_0001367/miR-545-3p/LUZP1 Axis Regulates Cell Proliferation, Migration and Invasion in Glioma Cells(2021/11/18)
作者：Dong Xuchen, Zhang Peng, Liu Liang
期刊：Frontiers in Oncology
影响因子 ：4.700
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Long Non-Coding RNA H19 Regulates Glioma Cell Growth and Metastasis via miR-200a-Mediated CDK6 and ZEB1 Expression(2021/11/2)
作者：Xuezhu Chen, Yuhong Li, Chenghai Zuo
期刊：Frontiers in Oncology
影响因子 ：4.700
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β3GNT9 as a prognostic biomarker in glioblastoma and its association with glioblastoma immune infiltration, migration and invasion(2023/09/12)
作者：YingHao Luo, Kan Wang, Lu Zhan
期刊：Frontiers in Oncology
影响因子 ：4.700
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The overexpression and clinical significance of TBX15 in human gliomas(2023/06/16)
作者：Dongming Yan, Yaping Yu, Qiongwei Ni
期刊：Scientific Reports
DOI：10.1038/s41598-023-36410-y
影响因子 ：4.600
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A Potential Anti-Glioblastoma Compound LH20 Induces Apoptosis and Arrest of Human Glioblastoma Cells via CDK4/6 Inhibition(2023/06/28)
作者：Yan Wang, Youbin Li, Dong Liu
期刊：MOLECULES
影响因子 ：4.600
-
LncRNA RARA-AS1 could serve as a novel prognostic biomarker in pan-cancer and promote proliferation and migration in glioblastoma(2023/10/13)
作者：Yue Huang, Song Deng, Qiaoji Jiang
期刊：Scientific Reports
DOI：10.1038/s41598-023-44677-4
影响因子 ：4.600
引用产品：CL-0238
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Inhibition of FAM83D displays antitumor effects in glioblastoma via down-regulation of the AKT/Wnt/β-catenin pathway(2022/02/12)
作者：Jubo Wang, Yu Quan, Jian Lv
期刊：Environmental Toxicology
影响因子 ：4.109
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GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma(2022/08/23)
作者：Zhaoshou Yang, Qin Yang, Xiaoxiao Sun
期刊：Journal of Immunology Research
影响因子 ：4.100
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Linc01094 Accelerates the Growth and Metastatic-Related Traits of Glioblastoma by Sponging miR-126-5p(2020/10/6)
作者：Xinxing Li, Qi Yu
期刊：OncoTargets and Therapy
影响因子 ：4.000
引用产品：CL-0238
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Dimethoxytolyl propylresorcinol induces apoptosis and mitophagy in human leukemia cells through the PI3K/AKT pathway(2024/01/01)
作者：Jianming Wei, Xiaojuan Zhong, Huiting Peng
期刊：Journal of Cancer
影响因子 ：3.900
引用产品：CL-0238
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Interaction between PD-L1 and soluble VEGFR1 in glioblastoma-educated macrophages(2023/03/20)
作者：Xin Liu, Zhenke Li, Jinxing Sun
期刊：BMC CANCER
DOI：10.1186/s12885-023-10733-5
影响因子 ：3.800
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Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression(2019/9/12)
作者：Qiong Jiang, Qing Xie, Chengliang Hu
期刊：Bmc Cancer
影响因子 ：3.800
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miRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGFβ2 signaling pathway(2023/11/19)
作者：Zelin Yang, Liang Yang, Zhenkai Sun
期刊：CANCER BIOLOGY & THERAPY
DOI：10.1080/15384047.2023.2281459
影响因子 ：3.600
引用产品：CL-0238
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EIF4A3-induced circCCNB1 (hsa_circ_0001495) promotes glioma progression by elevating CCND1 through interacting miR-516b-5p and HuR(2022/01/17)
作者：Xiaoli Li, Chengmou Wang, Guanghui Chen
期刊： Metabolic Brain Disease
DOI：10.1007/s11011-021-00899-x
影响因子 ：3.600
引用产品：164210 CL-0012 CL-0237 CL-0238 CL-0583 PB180120 PM150210
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EIF4A3-induced circCCNB1 (hsa_circ_0001495) promotes glioma progression by elevating CCND1 through interacting miR-516b-5p and HuR(2022/01/17)
作者：Xiaoli Li, Chengmou Wang, Guanghui Chen
期刊： Metabolic Brain Disease
DOI：10.1007/s11011-021-00899-x
影响因子 ：3.600
引用产品：164210 CL-0012 CL-0237 CL-0238 CL-0583 PB180120 PM150210
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Circular RNA circ_0001588 sponges miR-211-5p to facilitate the progression of glioblastoma via up-regulating YY1 expression(2021/07/14)
作者：Qian Wang, Dahai Zheng, Yuhan Li
期刊：Journal Of Gene Medicine
DOI：10.1002/jgm.3371
影响因子 ：3.500
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Deubiquitination of TNKS1 Regulates Wnt/β-Catenin to Affect the Expression of USP25 to Promote the Progression of Glioma(2022/04/11)
作者：Bin Tang, Hai Luo, Shenhao Xie
期刊：DISEASE MARKERS
影响因子 ：3.464
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Adipose‑derived stem cell‑mediated alphastatin targeting delivery system inhibits angiogenesis and tumor growth in glioma(2023/09/26)
作者：Chen Liang, Ting Wei, Ting Zhang
期刊：Molecular Medicine Reports
影响因子 ：3.400
-
Exosome-transmitted ANGPTL1 suppresses angiogenesis in glioblastoma by inhibiting the VEGFA/VEGFR2/Akt/eNOS pathway(2023/12/15)
作者：Dong Wang, Huichen Li, Tianxiang Zeng
期刊：JOURNAL OF NEUROIMMUNOLOGY
DOI：10.1016/j.jneuroim.2023.578266
影响因子 ：3.300
引用产品：CL-0238
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CFTR activation suppresses glioblastoma cell proliferation, migration and invasion(2018/11/17)
作者：Xiao Zhong, Hongqi Chen, Xiuling Yang
期刊：Biochemical and Biophysical Research Communications
DOI：10.1016/j.bbrc.2018.12.080
影响因子 ：3.100
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Inhibition of proliferation and migration and induction of apoptosis in glioma cells by silencing TLR4 expression levels via RNA interference(2020/11/6)
作者：Yingzi Liu, Yingchao Ju, Jianghui Liu
期刊：Oncology Letters
影响因子 ：2.900
引用产品：CL-0238
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miR-9-3p inhibits glioma cell proliferation and apoptosis by directly targeting FOXG1(2020/6/11)
作者：Jianwen Zhen, Hengxun Zhang, Hongzhi Dong
期刊：Oncology Letters
影响因子 ：2.900
引用产品：CL-0238
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Neuregulin 1 enhances cell adhesion molecule L1 like expression levels and promotes malignancy in human glioma(2020/4/21)
作者：Wenwen Lin, Guanyong Ou, Jiazhe Lin
期刊：Oncology Letters
影响因子 ：2.900
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HNF4G accelerates glioma progression by facilitating NRP1 transcription(2023/02/01)
作者：Hongmin Che, Qi Zheng, Zijun Liao
期刊：Oncology Letters
影响因子 ：2.900
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Scinderin promotes glioma cell migration and invasion via remodeling actin cytoskeleton(2024/01/24)
作者：Xin Lin, Zhao Zhao, Shupeng Sun
期刊：World Journal of Clinical Oncology
影响因子 ：2.800
引用产品：CL-0238
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miRNA-130a-3p/CPEB4 Axis Modulates Glioblastoma Growth and Progression(2023/12/21)
作者：Hongchao Liu, Zhihao Wei, Kangke Shi
期刊：TECHNOLOGY IN CANCER RESEARCH & TREATMENT
影响因子 ：2.800
引用产品：CL-0238
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Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells(2021/3/2)
作者：Linna Zhang, Huimei Cao, Hong Tao
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.700
引用产品：CL-0238
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High LYRM4-AS1 predicts poor prognosis in patients with glioma and correlates with immune infiltration(2023/10/03)
作者：Haiyue Wang, Ying Xie, Hongzhen Du
期刊：PeerJ
影响因子 ：2.700
引用产品：CL-0238
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The Antitumor Potential of Extract of the Oak Bracket Medicinal Mushroom Inonotus baumii in SMMC-7721 Tumor Cells(2019/9/22)
作者：Yue Yang, Pingya He, Ning Li
期刊：Evidence-based Complementary and Alternative Medicine
影响因子 ：2.650
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FOXG1 mediates the radiosensitivity of glioma cells through regulation of autophagy(2020/11/17)
作者：Ning Xiao, Churong Li, Wenjun Liao
期刊：International Journal Of Radiation Biology
DOI：10.1080/09553002.2021.1846816
影响因子 ：2.600
引用产品：CL-0238
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Long Noncoding RNA NEAT1 Suppresses Proliferation and Promotes Apoptosis of Glioma Cells Via Downregulating MiR-92b:(2020/1/14)
作者：Dongdong Liu, Zheng Zou, Gen Li
期刊：Cancer Control
影响因子 ：2.600
引用产品：CL-0238
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Construction of a novel microRNA-based signature for predicting the prognosis of glioma(2022/03/30)
作者：Gaoxin Liu, Xiaoming Rong, Xinrou Lin
期刊：International Journal Of Neuroscience
DOI：10.1080/00207454.2021.1993848
影响因子 ：2.200
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ADAMTS8 inhibits glioma development in vitro and in vivo(2023/07/14)
作者：Baosheng Zhou, Yong Liu, Guangshuo Ma
期刊：FOLIA NEUROPATHOLOGICA
影响因子 ：2.000
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Human EVI2B acts as a Janus-faced oncogene/antioncogene by differently affecting as per cancer type neoplastic cells growth and immune infiltration:(2023/03/23)
作者：Fangyingnan Zhang, Xinning Wang, Xiaoqi Zhang
期刊：Oncologie
DOI：10.1515/oncologie-2022-1002
影响因子 ：0.900
