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| 名称 | AML12 (小鼠正常肝细胞) (STR鉴定正确) |
| 别称 | AML-12; AML 12; Alpha Mouse Liver 12 |
| 种属 | 小鼠 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:4-1:6 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | The AML12 (alpha mouse liver 12) cell line was established from hepatocytes from a mouse (CD1 strain, line MT42) transgenic for human TGF alpha. |
| 年龄（性别） | 雄性；3月龄 |
| 组织来源 | 肝脏 |
| 细胞类型 | 自发永生化细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~37 hours |
| 致瘤性 | NO |
| 基因表达情况 | albumin; human transforming growth factor alpha (TGF alpha); mouse TGF alpha. |
| 保藏机构 | ATCC; CRL-2254 BCRC; 60326 BCRJ; 0354 |
STR鉴定
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STR位点信息
18-3 21 6-7 12 5-5 14,15 X-1 26 1-2 13 7-1 29 8-1 14,15 1-1 11 19-2 13 15-3 21.3 12-1 19 6-4 16 4-2 20.3 3-2 12 2-1 9 13-1 15.1
11-2 18,19 17-2 14,15 -
STR鉴定图
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参考文献
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Cullin-associated and neddylation-dissociated protein 1 (CAND1) alleviates NAFLD by reducing ubiquitinated degradation of ACAA2(2023/08/01)
作者：Xiang Huang, Xin Liu, Xingda Li
期刊：Nature Communications
DOI：10.1038/s41467-023-40327-5
影响因子 ：16.600
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O-GlcNAcylation of Raptor transduces glucose signals to mTORC1(2023/08/03)
作者：Chenchen Xu, Xiaoqing Pan, Dong Wang
期刊：MOLECULAR CELL
DOI：10.1016/j.molcel.2023.07.011
影响因子 ：16.000
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Multicomponent microspheres with spatiotemporal drug release for post-surgical liver cancer treatment and liver regeneration(2022/12/01)
作者：Jinwei Zhong, Qingfei Zhang, Gaizhen Kuang
期刊：CHEMICAL ENGINEERING JOURNAL
影响因子 ：15.100
引用产品：CL-0602
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Inhibition of free heme-catalyzed Fenton-like reaction prevents non-alcoholic fatty liver disease by hepatocyte-targeted hydrogen delivery(2023/07/01)
作者：Min Zhao, Zhaokui Jin, Chao Xia
期刊：BIOMATERIALS
DOI：10.1016/j.biomaterials.2023.122230
影响因子 ：14.000
引用产品：CL-0602
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A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy(2024/01/09)
作者：Ning Wang, Qiyu Zhang, Zhuoya Wang
期刊：CARBOHYDRATE POLYMERS
DOI：10.1016/j.carbpol.2024.121795
影响因子 ：11.200
引用产品：CL-0602
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Overexpression of PDE4D in mouse liver is sufficient to trigger NAFLD and hypertension in a CD36-TGF-β1 pathway: therapeutic role of roflumilast(2021/11/24)
作者：Xiang Tao, Haiqing He, Jiangtong Peng
期刊：Pharmacological Research
DOI：10.1016/j.phrs.2021.106004
影响因子 ：10.334
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DBF4 Dependent Kinase Inhibition Suppresses Hepatocellular Carcinoma Progression and Potentiates Anti-Programmed Cell Death-1 Therapy(2023/07/03)
作者：Liang Zhang, Jiawei Hong, Wei Chen
期刊：International Journal of Biological Sciences
影响因子 ：9.200
引用产品：CL-0602
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Dietary Lactobacillus reuteri prevent from inflammation mediated apoptosis of liver via improving intestinal microbiota and bile acid metabolism(2022/10/18)
作者：Zishen Lin, Jianmin Wu, Jinping Wang
期刊：FOOD CHEMISTRY
DOI：10.1016/j.foodchem.2022.134643
影响因子 ：8.800
引用产品：CL-0602
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Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway in vivo and in vitro(2023/04/03)
作者：Fen Zhang, Lanlan Xiao, Ya Yang
期刊：Frontiers of Medicine
影响因子 ：8.100
引用产品：CL-0602
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ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis(2022/10/04)
作者：Baitong Wu, Jiuxing Feng, Jingyi Guo
期刊：Stem Cell Research & Therapy
DOI：10.1186/s13287-022-03049-x
影响因子 ：8.079
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Surface Engineering of HEK293 Cell-Derived Extracellular Vesicles for Improved Pharmacokinetic Profile and Targeted Delivery of IL-12 for the Treatment of Hepatocellular Carcinoma(2023/01/12)
作者：Jing Zhang, Haijing Song, Yanan Dong
期刊：International Journal of Nanomedicine
影响因子 ：8.000
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Human umbilical cord-derived mesenchymal stem cells ameliorate liver fibrosis by improving mitochondrial function via Slc25a47-Sirt3 signaling pathway(2024/01/09)
作者：Ping Chen, Mengqin Yuan, Lichao Yao
期刊：BIOMEDICINE & PHARMACOTHERAPY
DOI：10.1016/j.biopha.2024.116133
影响因子 ：7.500
引用产品：CL-0602
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FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease(2022/11/03)
作者：Yajing You, Chenxi Liu, Tiantian Liu, Miaomiao Tian, Nijin Wu, Zhen Yu, Fenglin Zhao, Jianni Qi, Qiang Zhu
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2022.10.322
影响因子 ：7.400
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Aa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1(2023/01/07)
作者：Yixin Liu, Wenyan She, Yi Li
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-022-03862-1
影响因子 ：7.400
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ETNPPL impairs autophagy through regulation of the ARG2-ROS signaling axis, contributing to palmitic acid-induced hepatic insulin resistance(2023/02/24)
作者：Caihua Wang, Xiaofang Li, Wei Zhang
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2023.02.017
影响因子 ：7.400
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Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate experimental non-alcoholic steatohepatitis via Nrf2/NQO-1 pathway(2022/09/10)
作者：Yaxing Kang, Yiran Song, Yuxin Luo
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2022.08.037
影响因子 ：7.400
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Angelica sinensis polysaccharide ameliorates nonalcoholic fatty liver disease via restoring estrogen-related receptor α expression in liver(2023/08/10)
作者：Li Luo, Huafeng Zhang, Weiliang Chen
期刊：PHYTOTHERAPY RESEARCH
DOI：10.1002/ptr.7982
影响因子 ：7.200
引用产品：CL-0602
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The Protective Effect of Sericin on AML12 Cells Exposed to Oxidative Stress Damage in a High-Glucose Environment(2022/04/05)
作者：Feng Ya Jing, Yu Jie Weng, Yu Qing Zhang
期刊：Antioxidants
影响因子 ：7.000
引用产品：CL-0602
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Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway(2022/02/10)
作者：Yi Wang, Bingbing Liu, Peixuan Wu
期刊：Antioxidants
影响因子 ：7.000
引用产品：CL-0602
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Targeting PARK7 Improves Acetaminophen-Induced Acute Liver Injury by Orchestrating Mitochondrial Quality Control and Metabolic Reprogramming(2022/10/28)
作者：Jiao Cai, Deqin Kong, Zi Long
期刊：Antioxidants
影响因子 ：7.000
引用产品：CL-0602
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Adipose-Derived Mesenchymal Stem Cells Inhibit JNK-Mediated Mitochondrial Retrograde Pathway to Alleviate Acetaminophen-Induced Liver Injury(2023/01/09)
作者：Yelei Cen, Guohua Lou, Jinjin Qi
期刊：Antioxidants
影响因子 ：7.000
引用产品：CL-0602
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Sappanone A Alleviates the Severity of Carbon Tetrachloride-Induced Liver Fibrosis in Mice(2023/09/04)
作者：Jing Qi, Lanqian Li, Xueqing Yan
期刊：Antioxidants
影响因子 ：7.000
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Cannabidiol alleviates perfluorooctane sulfonate-induced macrophage extracellular trap mediate inflammation and fibrosis in mice liver(2023/08/15)
作者：Dongliu Luo, Jintao Zhang, Hang Yin
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2023.115374
影响因子 ：6.800
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Environmental toxin chlorpyrifos induces liver injury by activating P53-mediated ferroptosis via GSDMD-mtROS(2023/04/24)
作者：Chenyang Han, Jian Sheng, Hongyan Pei
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2023.114938
影响因子 ：6.800
引用产品：CL-0602
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Inhibition of HSPA8 by rifampicin contributes to ferroptosis via enhancing autophagy(2022/10/26)
作者：Juan Zhou, Yingzheng Tan, Lingli Hu
期刊：LIVER INTERNATIONAL
影响因子 ：6.700
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FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease(2024/01/06)
作者：Lin Li, Lina Kong, Shuai Xu
期刊：Hepatology International
DOI：10.1007/s12072-023-10621-x
影响因子 ：6.600
引用产品：CL-0602
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Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease(2023/10/31)
作者：Shuai Xu, Lina Kong, Lin Li
期刊：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
DOI：10.1016/j.bbadis.2023.166930
影响因子 ：6.200
引用产品：CL-0602
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Identification of antioxidant peptides after digestion and absorption of isinglass by serum peptidomics and cellular antioxidant activity analysis(2023/02/10)
作者：Lanfei Xiao, Yongjun Liang, Geng Liu
期刊：Food & Function
影响因子 ：6.100
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Isolongifolene alleviates liver ischemia/reperfusion injury by regulating AMPK-PGC1α signaling pathway-mediated inflammation, apoptosis, and oxidative stress(2022/10/17)
作者：Jinjin Li, Jie Li, Hongbo Fang
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2022.109185
影响因子 ：5.600
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Self-assembled FGF21 nanoparticles alleviate drug-induced acute liver injury(2023/01/10)
作者：Zhiwei Huang, Hengcai Wang, Changju Chun
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2022.1084799
影响因子 ：5.600
引用产品：CL-0602
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Hepatocyte-derived exosomes deliver H2AFJ to hepatic stellate cells and promote liver fibrosis via the MAPK/STMN1 axis activation(2023/01/04)
作者：Bin Liu, Jinchao Wang, Guangchuan Wang
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2022.109605
影响因子 ：5.600
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Trans-anethole pretreatment ameliorates hepatic ischemia–reperfusion injury via regulation of soluble epoxide hydrolase(2023/09/08)
作者：Jiansen Lu, Wen Hou, Shuang Yang
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.110809
影响因子 ：5.600
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Identification of potential pathogenic hepatic super-enhancers regulatory network in high-fat diet induced hyperlipidemia(2024/01/17)
作者：Yingying Hu, Run Xu, Jing Feng
期刊：JOURNAL OF NUTRITIONAL BIOCHEMISTRY
DOI：10.1016/j.jnutbio.2024.109584
影响因子 ：5.600
引用产品：CL-0602
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Use of a ferroptosis-related gene signature to construct diagnostic and prognostic models for assessing immune infiltration in metabolic dysfunction-associated fatty liver disease(2023/10/19)
作者：Xin Lian, Xulei Tang
期刊：Frontiers in Cell and Developmental Biology
DOI：10.3389/fcell.2023.1199846
影响因子 ：5.500
引用产品：CL-0602
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Water extract of earthworms mitigates mouse liver fibrosis by potentiating hepatic LKB1/Nrf2 axis to inhibit HSC activation and hepatocyte death(2023/11/26)
作者：Tiantian Zhang, Chuo Wang, Anning Song
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：5.400
引用产品：CL-0602
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Identification and validation of cuproptosis-related molecular clusters in non-alcoholic fatty liver disease(2024/01/03)
作者：Changxu Liu, Zhihao Fang, Kai Yang
期刊：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子 ：5.300
引用产品：CL-0602
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METTL3 Modulates TXNIP Expression to Affect the Activation of NLRP3 Inflammasome in Hepatic Cells Under Oxygen–Glucose Deprivation/Reperfusion Injury(2024/01/18)
作者：Yong Zhang, Jianrui Lv, Jian Bai
期刊：INFLAMMATION
DOI：10.1007/s10753-023-01958-4
影响因子 ：5.100
引用产品：CL-0602
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Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway(2023/12/17)
作者：Min Wu, Xudong Liu, Qiwen Yu
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2023.176224
影响因子 ：5.000
引用产品：CL-0602
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Liraglutide inhibits receptor for advanced glycation end products (RAGE)/reduced form of nicotinamide-adenine dinucleotide phosphate (NAPDH) signaling to ameliorate non-alcoholic fatty liver disease (NAFLD) in vivo and vitro(2022/02/14)
作者：Jingquan Ji, Ming Feng, Yan Huang
期刊：Bioengineered
DOI：10.1080/21655979.2022.2036902
影响因子 ：4.900
引用产品：CL-0602
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Exploring the mechanism and phytochemicals in Psoraleae Fructus-induced hepatotoxicity based on RNA-seq, in vitro screening and molecular docking(2024/01/19)
作者：Huiying Shang, Xian Liu, Jinchao Pan
期刊：Scientific Reports
DOI：10.1038/s41598-023-50454-0
影响因子 ：4.600
引用产品：CL-0602
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Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis(2023/07/08)
作者：Xiwei Yuan, Lu Li, Ying Zhang
期刊：Lipids in Health and Disease
DOI：10.1186/s12944-023-01855-7
影响因子 ：4.500
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Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles(2022/12/12)
作者：Zhengyuan Xie, Hengwei Cao, Qing Wang
期刊：Journal of Cell Communication and Signaling
DOI：10.1007/s12079-022-00716-9
影响因子 ：4.100
引用产品：CL-0602
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BNIP3 in hypoxia-induced mitophagy: novel insights and promising target for non-alcoholic fatty liver disease(2024/01/11)
作者：Meiyuan Tian, Jing Hou, Zhe Liu
期刊：INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
DOI：10.1016/j.biocel.2024.106517
影响因子 ：4.000
引用产品：CL-0602
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Octreotide ameliorates hepatic ischemia-reperfusion injury through SNHG12/TAF15-mediated Sirt1 stabilization and YAP1 transcription(2022/03/18)
作者：Shuangfa Zou, Yanhua Peng, Chumei Zheng
期刊：Toxicology And Applied Pharmacology
DOI：10.1016/j.taap.2022.115975
影响因子 ：3.800
引用产品：CL-0602
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Suppression of SIRT1/FXR signaling pathway contributes to oleanolic acid-induced liver injury(2023/04/05)
作者：Songjie Liao, Xiaolong Fu, Jianxiang Huang
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2023.116509
影响因子 ：3.800
引用产品：CL-0602
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SIRT5 alleviates hepatic ischemia and reperfusion injury by diminishing oxidative stress and inflammation via elevating SOD1 and IDH2 expression(2022/08/19)
作者：Daofeng Zheng, Qiwen zeng, Diao He
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2022.113319
影响因子 ：3.700
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Low‑dose ionizing radiation attenuates high glucose‑induced hepatic apoptosis and immune factor release via modulation of a miR‑155‑SOCS1 axis(2023/07/24)
作者：Hongqiong Fan, Shanshan Liu, Benzheng Jiao
期刊：Molecular Medicine Reports
影响因子 ：3.400
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Running title: AMPK contributes to liver injury(2023/02/27)
作者：Jianxiang Huang, Songjie Liao, Xiaolong Fu
期刊：JOURNAL OF APPLIED TOXICOLOGY
DOI：10.1002/jat.4456
影响因子 ：3.300
引用产品：CL-0602
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Circadian rhythm disorders elevate macrophages cytokines release and promote multiple tissues/organs dysfunction in mice(2022/03/02)
作者：Zhen Sun, Lihua Li, Zhixin Yan
期刊：Physiol Behav
DOI：10.1016/j.physbeh.2022.113772
影响因子 ：2.900
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Basic fibroblast growth factor protects against liver ischemia-reperfusion injury via the Nrf2/Hippo signaling pathway(2022/09/08)
作者：Xixi Chen, Gaozan Tong, Saizhen Chen
期刊：TISSUE & CELL
DOI：10.1016/j.tice.2022.101921
影响因子 ：2.600
引用产品：CL-0602
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Ganoderic acid A attenuated hepatic impairment by down-regulating the intracellular JAK2-STAT3 signaling pathway in induced mushroom poisoning(2024/01/15)
作者：Chenggen Xiao, Guoqing Huang, Xiaoxia Cao
期刊：American Journal of Translational Research
DOI：PMID:38322557
影响因子 ：2.200
引用产品：CL-0602
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In vitro and in vivo metabolic profiling of PD105, a PI3Kδ inhibitor, using UHPLC-Q-Exactive Plus-MS(2023/03/06)
作者：Panhong Wei, Minghai Tang, Ziyan Ma
期刊：XENOBIOTICA
DOI：10.1080/00498254.2023.2188070
影响因子 ：1.800
引用产品：CL-0602
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